We generalize the classical Markov inequality, relating the maximum of the polynomial and the maximum of its derivative on the interval, in two directions: first we replace polynomials by functions in ``Bernstein classes" (studied in $\cite{4}$,$\cite{5}$). Second, and more important generalization is that similar inequality is established for Wronskians of different order; of the system of polynomials (or function in a given Bernstein class)